10 research outputs found
An open reproducible framework for the study of the iterated prisoner's dilemma
The Axelrod library is an open source Python package that allows for
reproducible game theoretic research into the Iterated Prisoner's Dilemma. This
area of research began in the 1980s but suffers from a lack of documentation
and test code. The goal of the library is to provide such a resource, with
facilities for the design of new strategies and interactions between them, as
well as conducting tournaments and ecological simulations for populations of
strategies.
With a growing collection of 139 strategies, the library is a also a platform
for an original tournament that, in itself, is of interest to the game
theoretic community. This paper describes the Iterated Prisoner's Dilemma, the
Axelrod library and its development, and insights gained from some novel
research.Comment: 11 pages, Journal of Open Research Software 4.1 (2016
Regulatory Focus in Predictions about Others
Based on social projection research, four studies investigated whether people rely on their own regulatory focus when making predictions about others. Chronic (Study 1) and induced (Study 2) regulatory focus shaped estimations of othersâ strategic promotion or prevention inclinations and choices between enriched (fitting promotion) and impoverished options (fitting prevention). Providing indirect process evidence via boundary conditions, participants only relied on their induced regulatory focus in predictions of othersâ inclinations to seek romantic alternatives to the extent that this did not run counter to stereotypic gender beliefs (Study 3). In addition, participants only relied on their induced regulatory focus in preference predictions concerning promotion and prevention products when they lacked idiosyncratic target knowledge (Study 4). These effects were not mediated by mood, judgment-certainty, perceived task-enjoyment, or task-difficulty. Implications of these findings for social projection research as well as possible interpersonal consequences are delineated
Le naturalisme en Autriche
La prĂ©sence dâĂ©lĂ©ments naturalistes dans la littĂ©rature autrichienne est peu connue. En lâanalysant dans des Ćuvres parues entre les annĂ©es 1880 et les annĂ©es 1970, dâAnzengruber Ă Innerhofer, ce volume permet de dĂ©couvrir lâhĂ©ritage naturaliste de Schnitzler, les rĂ©actions de Kraus, mais aussi la dĂ©couverte de quelques oubliĂ©s de lâhistoire littĂ©raire et dâune terre fertile en productions naturalistes, la Moravie
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.11Nsciescopu
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60â80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies